A practical reference on thymosin alpha 1: what it is, how it behaves, what the literature reports, and where the honest uncertainties sit.
This page was last updated on 2026-08-01 and is reviewed periodically as new material appears.
Immune signaling studies link thymosin alpha 1 to Toll-like receptor pathways, particularly TLR2 and TLR9, on dendritic cells and other antigen-presenting cells. Activation of these receptors promotes maturation of T cells and increases natural killer cell activity. The peptide shifts cytokine output toward a T helper 1 profile, raising interferon gamma and interleukin 2 while modulating interleukin 10. Whether these effects translate into clinical benefit for any specific disease remains a subject of debate. Reported outcomes vary across trials and populations.
Thymosin alpha 1 is approved as a medicine in several countries, including Italy and China, for indications such as chronic hepatitis B and as an immune adjuvant. It is not approved by the United States Food and Drug Administration as a therapeutic product. In research settings the peptide appears in studies of sepsis, vaccine response, and oncology support, often with mixed or inconclusive results. The evidence base is uneven, and reviews note that many trials were small. Regulatory status therefore differs widely between jurisdictions.
Immunological studies connect the peptide to multiple parts of the immune response. It has been reported to engage Toll-like receptor signaling, to promote dendritic cell maturation, and to influence the balance of T helper cell subsets. Changes in natural killer cell activity and in cytokine release appear in cell culture and animal models. These observations describe broad immunomodulatory behavior rather than a single defined receptor target, and the primary molecular interaction has not been settled.
Thymosin alpha-1 is a synthetic 28-amino-acid peptide whose sequence was first identified in extracts of bovine thymus tissue during the 1970s. The chain carries an acetyl group on its N-terminal serine. Its acidic residue content is high, which produces strong water solubility and an isoelectric point well below neutrality. Material supplied for laboratory and clinical use is manufactured by solid-phase peptide synthesis rather than purified from animal tissue. Different salt forms, such as the acetate, alter the counter-ion content without changing the peptide backbone.
Whether the free 28-residue peptide circulates in human tissue remains debated. The best-documented human source is prothymosin alpha, a larger acidic protein that carries the sequence at its N-terminus. Reports of measurable peptide levels in serum and lymphoid tissue exist, yet some of that signal may come from cross-reacting fragments or from the parent protein. Most reviews therefore treat prothymosin alpha as the established human molecule and describe independent circulation of the small peptide as an unresolved question.
| Property | Value | Notes |
|---|---|---|
| Molecular mass | ≈3,108 Da | Synthetic 28-residue peptide |
| Amino acid count | 28 | N-terminal serine carries an acetyl group |
| Appearance | White to off-white powder | Lyophilized solid |
| Water solubility | Freely soluble | Dissolves in aqueous buffer |
| Common synonyms | Thymalfasin; Tα1 | Thymalfasin is the international nonproprietary name |
Biologically, the peptide is studied mainly in the context of immune cell development and regulation. It is produced in the thymus and in several other tissues, and it appears to influence the maturation and activity of T cells and other immune populations. Laboratory work describes effects on cytokine production, on the balance between T cell subsets, and on the function of dendritic cells. Much of this evidence comes from cell culture and animal models, so the extent to which the same pathways operate in humans remains an open question.
Clinical interest has centered on chronic viral hepatitis, on immune restoration in various conditions, and on use as an adjuvant intended to improve responses to vaccines. Trials have reported mixed results, and regulatory status differs sharply between countries; in some places it is a prescription product, while elsewhere it is sold without an approved therapeutic indication. Because published studies vary widely in design, population, and endpoints, comparisons across them are difficult and no single conclusion covers the whole literature.
市售的胸腺素α1通常以冻干粉形式提供，溶解后用于注射。其氨基酸组成包括多个酸性残基，因此在中性pH下带负电荷。该肽可溶于水和生理盐水，但在有机溶剂中溶解度有限。储存条件通常为冻干状态下负20摄氏度，溶解后需冷藏并避免反复冻融。常见的同义词包括胸腺肽α1、thymalfasin和Tα1。
胸腺素α1（thymosin alpha 1，Tα1）是一种由28个氨基酸组成的酸性肽，N端被乙酰化，分子量约为3108道尔顿。该肽最早从牛胸腺组织提取物中分离，属于胸腺素组分5的一个成分。其序列在不同哺乳动物中高度保守，提示其具有基本的生物学功能。名称中的“α1”指其在电泳中的迁移位置，并非表示亚型编号。它既存在于胸腺，也存在于脾脏和淋巴结等免疫组织。
== Medical uses == Mineralocorticoid receptor antagonists are diuretic drugs that work primarily on the kidneys. They decrease sodium reabsorption, which leads to increased water excretion by the kidneys. By regulating water excretion, mineralocorticoid receptor antagonists lower blood pressure and reduce fluid around the heart which can be very beneficial in some cardiovascular conditions. Mineralocorticoid receptor antagonists have been used for many clinical conditions in the cardiovascular system. It has proven beneficial for diseases like primary aldosteronism, primary and resistant hypertension, heart failure and chronic kidney disease. They are often used with other medications, such as ACE inhibitors or beta blockers.
Lactiplantibacillus plantarum (formerly Lactobacillus arabinosus and Lactobacillus plantarum) is a widespread member of the genus Lactiplantibacillus and commonly found in many fermented food products as well as anaerobic plant matter. L. plantarum was first isolated from saliva. Based on its ability to temporarily persist in plants, the insect intestine and in the intestinal tract of vertebrate animals, it was designated as a nomadic organism. L. plantarum is Gram positive, bacilli shaped bacterium. L. plantarum cells are rods with rounded ends, straight, generally 0.9–1.2 μm wide and 3–8 μm long, occurring singly, in pairs or in short chains. L. plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species. It is estimated to grow between pH 3.4 and 8.8. Lactiplantibacillus plantarum can grow in the temperature range 12 °C to 40 °C. The viable counts of the "L. plantarum" stored at refrigerated condition (4 °C) remained high, while a considerable reduction in the counts was observed stored at room temperature (25 ± 1 °C).
The fusion of droplets with different contents can also be exploited for reagent addition. Electro-coalescence merges pairs of droplets by applying an electric field to temporarily destabilize the droplet-droplet interface to achieve reproducible droplet fusion in surfactant-stabilized emulsions. Electro-coalescence requires droplets (which are normally separated by the continuous phase) to come into contact. By manipulating droplet size in separate streams, differential flow of droplet sizes can bring droplets into contact before merging. Another method for facilitating droplet fusion is acoustic tweezing. While droplets are flowing in microfluidic channels, they can be immobilised using an acoustic tweezer based on surface acoustic waves. Once a droplet is held with the acoustic tweezer, consecutive droplets collide into it and fusion takes place.
Large lamps may have a screw base or a bayonet base, with one or more contacts on the base. The shell may serve as an electrical contact or only as a mechanical support. Bayonet base lamps are frequently used in automotive lamps to resist loosening by vibration. Some tubular lamps have an electrical contact at either end. Miniature lamps may have a wedge base and wire contacts, and some automotive and special purpose lamps have screw terminals for connection to wires. Very small lamps may have the filament support wires extended through the base of the lamp for connections. A bi-pin base is often used for halogen or reflector lamps. In the late 19th century, manufacturers introduced a multitude of incompatible lamp bases. General Electric's "Mazda" standard base sizes were soon adopted across the US. Lamp bases may be secured to the bulb with a cement, or by mechanical crimping to indentations molded into the glass bulb. Lamps intended for use in optical systems have bases with alignment features so that the filament is positioned accurately within the optical system. A screw-base lamp may have a random orientation of the filament when the lamp is installed in the socket. Contacts in the lightbulb socket allow the electric current to pass through the base to the filament. The socket provides electrical connections and mechanical support, and allows changing the lamp when it burns out.
The citric acid cycle begins with the transfer of a two-carbon acetyl group from acetyl-CoA to the four-carbon acceptor compound (oxaloacetate) to form a six-carbon compound (citrate). The citrate then goes through a series of chemical transformations, losing two carboxyl groups as CO2. The carbons lost as CO2 originate from what was oxaloacetate, not directly from acetyl-CoA. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle. Loss of the acetyl-CoA-donated carbons as CO2 requires several turns of the citric acid cycle. However, because of the role of the citric acid cycle in anabolism, they might not be lost, since many citric acid cycle intermediates are also used as precursors for the biosynthesis of other molecules. Most of the electrons made available by the oxidative steps of the cycle are transferred to NAD+, forming NADH. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced. The citric acid cycle includes a series of redox reactions in mitochondria. In addition, electrons from the succinate oxidation step are transferred first to the FAD cofactor of succinate dehydrogenase, reducing it to FADH2, and eventually to ubiquinone (Q) in the mitochondrial membrane, reducing it to ubiquinol (QH2) which is a substrate of the electron transfer chain at the level of Complex III. For every NADH and FADH2 that are produced in the citric acid cycle, 2.5 and 1.5 ATP molecules are generated in oxidative phosphorylation, respectively.
Sources: en.wikipedia.org
After making the necessary adjustments to account for the n0 standard gas density, ion mobilities are often expressed as reduced mobilities. This number can also be described as standard temperature T0 = 273 K and standard pressure p0 = 1013 hPa. Both of these can be found in the table below. Ion concentrations are another term that may be used when referring to ion mobilities. Because of this, the decreased ion mobility is still temperature-dependent, although this adjustment does not consider any impacts other than the reduction in gas density.
Respondents in the 2021 Canadian census self-reported over 450 "ethnic or cultural origins". The major panethnic groups chosen were: European (52.5%), North American (22.9%), Asian (19.3%), North American Indigenous (6.1%), African (3.8%), Latin, Central and South American (2.5%), Caribbean (2.1%), Oceanian (0.3%), and other (6%). Over 60 percent of Canadians reported a single origin, and 36 percent reported having multiple ethnic origins, thus the overall total is greater than 100 percent.
== Bibliography == Cynthia Zaferatos (2008). "The History Of Olive Oil" (PDF). EUROMED Sustainable Connections Policy Analysis. Anna Lindh Foundation. p. 2. Archived from the original (PDF) on 2012-04-07. Retrieved 2011-10-01 – via Western Washington University. Nayak, Shivananda; Nalabothu, Poorna; Sandiford, Steve; Bhogadi, Vidyasagar; Adogwa, Andrew (2006). "Evaluation of wound healing activity of Allamanda cathartica. L. And Laurus nobilis. L. Extracts on rats". BMC Complementary and Alternative Medicine. 6: 12. doi:10.1186/1472-6882-6-12. PMC 1456996. PMID 16597335.
In September 1992, Austin formed a tag team known as the Hollywood Blonds with Brian Pillman, at the behest of lead booker Dusty Rhodes. Austin would later say that he was not excited about being placed into a tag team, as he was earmarked for a run with the WCW United States Heavyweight Championship with Harley Race as his manager. Initially billed under their individual personas, Pillman decided the pair needed their own finishing move, ring gear and team name, with traveling partner Scott Levy proposing the Hollywood Blonds, used in the 1970s by Buddy Roberts and Jerry Brown. At Halloween Havoc in October 1992, Austin (substituting for Terry Gordy) teamed with "Dr. Death" Steve Williams to wrestle Dustin Rhodes and Windham for the unified WCW and NWA World Tag Team Championship, wrestling to a 30-minute time limit draw. On March 27, 1993, the Hollywood Blonds won the unified NWA and WCW World Tag Team Championship by defeating Ricky Steamboat and Shane Douglas, and held the championship for five months. In the main event of Clash of the Champions XXIII in June 1993, the Blondes defended their championship against Ric Flair and Arn Anderson in a two-out-of-three-falls, where despite losing the first two falls, retained the championship as the second fall had been determined by a disqualification caused by Barry Windham. At Clash of the Champions XXIV In August 1993, Austin and Pillman were scheduled to defend their championship against Anderson and Paul Roma but a legitimately injured Pillman was replaced by Steven Regal, with whom Austin lost to Anderson and Roma.
Sources: en.wikipedia.org
==== MeSH D13.444.600 – nucleic acid probes ==== MeSH D13.444.600.150 – antisense elements (genetics) MeSH D13.444.600.150.200 – DNA, antisense MeSH D13.444.600.150.200.640 – oligodeoxyribonucleotides, antisense MeSH D13.444.600.150.640 – oligonucleotides, antisense MeSH D13.444.600.150.640.640 – oligodeoxyribonucleotides, antisense MeSH D13.444.600.150.640.645 – oligoribonucleotides, antisense MeSH D13.444.600.150.760 – rna, antisense MeSH D13.444.600.150.760.640 – oligoribonucleotides, antisense MeSH D13.444.600.223 – DNA probes MeSH D13.444.600.223.500 – DNA, complementary MeSH D13.444.600.223.550 – DNA probes, hla MeSH D13.444.600.223.555 – DNA probes, hpv MeSH D13.444.600.601 – oligonucleotide probes MeSH D13.444.600.723 – rna probes MeSH D13.444.600.723.480 – rna, complementary
==== Deficit in spatial learning ==== In 1998, Giese and colleagues studied knockout mice that have been genetically engineered to prevent CaMKII autophosphorylation. They observed that mice had trouble finding the hidden platform in the Morris water maze task. The Morris water maze task is often used to represent hippocampus-dependent spatial learning. The mice's inability to find the hidden platform implies deficits in spatial learning. However, these results were not entirely conclusive because memory formation deficit could also be associated with sensory motor impairment resulting from genetic alteration.
== Further reading == David L. Heiserman (1968). Light -Emitting Diodes (PDF). Electronics World. Shuji Nakamura; Gerhard Fasol; Stephen J Pearton (2000). The Blue Laser Diode: The Complete Story. Springer Verlag. ISBN 978-3-540-66505-2.
Francis Joseph Donnelly. For services to Disability Sport and to the community in Northern Ireland. Nilesh Bhasker Dosa. Founder, icanyoucantoo. For services to Social Equality. George David Dowell. Owner, Worthing Football Club. For services to Association Football and to Disability Awareness. Elissa Rebecca Louise Downie. For services to Gymnasts and to the Sport of Gymnastics. Rebecca Lauren Downie. For services to Gymnasts and to the Sport of Gymnastics. Spencer Drury. Lately Councillor, Royal Borough of Greenwich. For Political and Public Service. James Michael Duffy. Lately Child Protection Manager, Lothian and Borders Police and Police Service of Scotland. For services to Children. Giles Duley. Founder, Legacy of War Foundation. For services to Survivors of Conflict. Mary Alexandra Earps. For services to Association Football. Dr. Gillian Mary Eatough. Lately Chief Executive Officer, Learning Community Trust. For services to Education. Captain Thomas David Eccles. Fisheries Officer, Department of Agriculture, Environment and Rural Affairs. For services to Fisheries, Environment and to Maritime Safety. Linda Jacqueline Edmunds. Consultant Nurse, Heart Failure and Cardiac Rehabilitation, Aneurin Bevan University Health Board. For services to Cardiac Rehabilitation and Heart Failure. Professor Anthony David Edwards. Professor of Paediatrics and Neonatal Medicine, King's College London. For services to Health Research. Huw William Edmond Edwards. Founder Member, Monmouth Male Voice Choir. For services to Music and to Charity. Dr. Alice Elizabeth Ellis (Alice Hartley).
==== RNA sequencing (RNA-seq) ==== Whole transcriptome shotgun sequencing (WTSS) is the latest in gene expression studies, using next generation sequencing (NGS) to quantify RNA in samples on a high throughput scale. As biology trends toward using RNA-seq over microarray analysis in evaluating the transcriptome, so does degradomics. The field adapts the approach to analyzing the presence and quantity of transcripts of proteases, their substrates, and their inhibitors. While developed microarrays remain a major workhorse in studying gene expression in degradomics, its limitations of cross hybridization and dynamic range issues suggest RNA-seq will take a larger role as costs decrease and analysis improves.
Sources: en.wikipedia.org
It is a chain of 28 amino acids, with an acetyl group attached to the first serine residue. The synthetic version replicates this sequence. Its molecular mass is about 3,108 daltons.
It is usually described as an immunomodulatory peptide rather than a classic hormone. It acts on immune cells through receptor pathways. No single endocrine organ target defines its function.
Several countries, including Italy and China, allow it for specific indications. The FDA has not approved it as a drug in the United States. Availability depends on local regulation.
It is usually described as an immunomodulatory peptide rather than a classic circulating hormone. No endocrine gland is known to release it as a primary secretory product, and its measured presence in blood is not firmly established.